Patents

Patents

Single vessel production of butanol from biomass using engineered thermophilic microorganisms

Patent number: 8669082

Abstract: The present invention relates to the production of biofuels by utilizing efficient biomass digestion and fermentation by a new thermophilic microorganism generated after fusion of two different bacteria Clostridium thermocellum and C. acetobutylicum and properly mutating the fused bacteria to produce biofuels and other economically important chemicals in a single vessel from lignocellulosic derived renewable biomass. All the necessary biochemical digestions and fermentation are carried out by this single thermophilic microorganism in one single vessel eliminating the need for multiple step digestion and fermentation processes, requiring multiple chambers. It also significantly reduces the rate limiting steps where increasing accumulation of alcohol, butanol and other substances become toxic to the very bacteria that produce these biofuels. The single vessel is incubated at high temperatures (45° C. or above) to eliminate the need for periodic stoppage and restarting of the process.

Type: Grant

Filed: August 22, 2012

Issued: March 11, 2014

Assignee: Claflin University

Inventors: Omar Bagasra, Kamal Chowdhury, Verlie A. Tisdale, George E. Miller, III, Rebecca Bullard-Dillard

 

SINGLE VESSEL PRODUCTION OF BUTANOL FROM BIOMASS USING ENGINEERED THERMOPHILIC MICROORGANISMS

Application number: 20140057327

Abstract: The present invention relates to the production of biofuels by utilizing efficient biomass digestion and fermentation by a new thermophilic microorganism generated after fusion of two different bacteria Clostridium thermocellum and C. acetobutylicum and properly mutating the fused bacteria to produce biofuels and other economically important chemicals in a single vessel from lignocellulosic derived renewable biomass. All the necessary biochemical digestions and fermentation are carried out by this single thermophilic microorganism in one single vessel eliminating the need for multiple step digestion and fermentation processes, requiring multiple chambers. It also significantly reduces the rate limiting steps where increasing accumulation of alcohol, butanol and other substances become toxic to the very bacteria that produce these biofuels. The single vessel is incubated at high temperatures (45° C. or above) to eliminate the need for periodic stoppage and restarting of the process.

Type: Application

Filed: August 22, 2012

Issued: February 27, 2014

Inventors: Omar Bagasra, Kamal Chowdhury, Verlie A. Tisdale, George E. Miller, III, Rebecca Bullard-Dillard

miRNA triplex formations for the downregulation of viral replication

Patent number: 8323891

Abstract: As discovered herein, using miRNAs having high homology with both HIV-1 and a co-infecting virus such as HHV-6, HHV-7, or GVB-C, one can inhibit viral replication, more particularly HIV-1 replication using such mutually homologous miRNAs that give rise to the creation of stable triplex formations effective in the downregulation and/or inhibition of viral replication.

Type: Grant

Filed: July 30, 2009

Issued: December 4, 2012

Assignee: Claflin University

Inventor: Omar Bagasra

 

miRNA TRIPLEX FORMATIONS FOR THE DOWNREGULATION OF VIRAL REPLICATION

Application number: 20100048675

Abstract: As discovered herein, using miRNAs having high homology with both HIV-1 and a co-infecting virus such as HHV-6, HHV-7, or GVB-C, one can inhibit viral replication, more particularly HIV-1 replication using such mutually homologous miRNAs that give rise to the creation of stable triplex formations effective in the downregulation and/or inhibition of viral replication.

Type: Application

Filed: July 30, 2009

Issued: February 25, 2010

Assignee: CLAFLIN UNIVERSITY

Inventor: Omar Bagasra

 

In situ polymerase chain reaction

Patent number: 5750347

Abstract: The present invention concerns in situ polymerase chain reaction and provides methods and reagents for identifying cells containing at least one selected nucleic acid sequence which may be derived from the human immunodeficiency virus.

Type: Grant

Filed: December 12, 1996

Issued: May 12, 1998

Assignee: Thomas Jefferson University

Inventors: Omar Bagasra, Roger J. Pomerantz

 

In situ polymerase chain reaction

Patent number: 5589333

Abstract: The present invention concerns in situ polymerase chain reaction and provides methods and reagents for identifying cells containing at least one selected nucleic acid sequence which may be derived from the human immunodeficiency virus.

Type: Grant

Filed: April 11, 1994

Issued: December 31, 1996

Assignee: Thomas Jefferson University

Inventors: Omar Bagasra, Roger J. Pomerantz

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